The research in my laboratory is crafted to investigate the phenomenon of allosteric regulation of protein activity specifically focused on regulatory processes mediated by the ACT and related domains in proteins. These proteins include enzymes involved in amino acid metabolism, transcription regulation, and molecular transport.
The long term goals of this research are to determine the relationship between structure and function in conformationally regulated control mechanisms, to eventually relate that to the physiology and pathophysiology mediated by these enzymes and by analogous systems, and to eventually understand conformationally mediated processes in proteins well enough to be able to apply basic principles to more complex systems.
In addition to my research laboratory, I also direct the Protein and Nucleic Acid Chemistry Laboratory. This is a resource laboratory providing DNA Sequence analysis and Protein Sequence analysis. To learn more about this lab, see the link on the left.